Andrew Harkin Selected Research

Clenbuterol

4/2018	The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats.
8/2016	Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats.
11/2013	Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB.
11/2010	The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.
7/2010	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex.

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Andrew Harkin Research Topics

Disease

12	Inflammation (Inflammations) 01/2021 - 08/2008
6	Major Depressive Disorder (Major Depressive Disorders) 01/2018 - 02/2012
5	Neuroinflammatory Diseases 01/2021 - 06/2009
4	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2018
3	Mental Disorders (Mental Disorder) 01/2017 - 12/2008
3	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2016 - 03/2010
3	Hyperthermia 07/2010 - 01/2006
2	Encephalitis (Encephalitis, Rasmussen) 01/2020 - 03/2010
2	Anhedonia 01/2019 - 02/2013
2	Brain Diseases (Brain Disorder) 01/2017 - 08/2008
2	Tachycardia (Tachyarrhythmias) 07/2010 - 01/2007
2	Necrosis 06/2009 - 08/2008
1	Delirium 01/2021
1	Feeding and Eating Disorders (Eating Disorder) 01/2021
1	Anxiety Disorders (Anxiety Disorder) 01/2021
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2021
1	dopamine beta hydroxylase deficiency 01/2021
1	Treatment-Resistant Depressive Disorder 01/2021
1	Cognitive Dysfunction 01/2021
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2021
1	Colitis 01/2019
1	Gliosis 01/2019
1	Parkinsonian Disorders (Parkinsonism) 01/2019
1	Synucleinopathies 08/2018
1	Brain Injuries (Brain Injury) 04/2018
1	Acute-Phase Reaction 04/2018
1	Infections 01/2017
1	Atrophy 01/2016
1	Anorexia 08/2015
1	Weight Loss (Weight Reduction) 08/2015
1	Alzheimer Disease (Alzheimer's Disease) 01/2015
1	Fatigue 11/2013
1	Neoplasms (Cancer) 11/2013
1	Breast Neoplasms (Breast Cancer) 11/2013
1	Weight Gain 02/2013
1	Bipolar Disorder (Manic Depressive Psychosis) 11/2012
1	Schizophrenia (Dementia Praecox) 11/2012
1	Pain (Aches) 02/2012
1	Stroke (Strokes) 02/2012
1	Bradycardia 07/2010

Drug/Important Bio-Agent (IBA)

6	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2021 - 06/2009
6	CytokinesIBA 04/2018 - 06/2009
5	ClenbuterolIBA 04/2018 - 07/2010
5	KynurenineIBA 01/2018 - 08/2008
4	Tryptophan (L-Tryptophan)FDA Link 01/2018 - 08/2012
4	Serotonin (5 Hydroxytryptamine)IBA 02/2013 - 01/2006
4	Caffeine (No Doz)FDA LinkGeneric 07/2010 - 12/2004
3	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 07/2010 - 01/2006
2	LipopolysaccharidesIBA 01/2021 - 01/2019
2	Formoterol Fumarate (Oxis)FDA Link 01/2020 - 11/2013
2	SaccharinIBA 01/2019 - 02/2013
2	C-Reactive ProteinIBA 01/2018 - 11/2013
2	Messenger RNA (mRNA)IBA 01/2018 - 08/2012
2	Kynurenic Acid (Kynurenate)IBA 01/2018 - 08/2012
2	Biological ProductsIBA 01/2018 - 01/2016
2	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 07/2010
2	Poly I-CIBA 08/2015 - 02/2013
2	Interleukin-6 (Interleukin 6)IBA 08/2015 - 11/2013
2	Nerve Growth Factors (Neurotrophins)IBA 02/2013 - 11/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2009 - 08/2008
1	Hallucinogens (Psychedelics)IBA 01/2021
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2020
1	Immunomodulating AgentsIBA 01/2020
1	Dextran SulfateIBA 01/2019
1	CalciumIBA 01/2019
1	2-Aminoadipic Acid (2 Aminoadipic Acid)IBA 01/2019
1	Glial Fibrillary Acidic ProteinIBA 01/2019
1	Drinking WaterIBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 08/2018
1	SynucleinsIBA 08/2018
1	Neuroprotective AgentsIBA 08/2018
1	Quinolinic AcidIBA 01/2018
1	IdazoxanIBA 01/2018
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 01/2018
1	Amitriptyline (Elavil)FDA LinkGeneric 01/2016
1	Amyloid beta-PeptidesIBA 01/2015
1	GlucocorticoidsIBA 11/2014
1	N-Methylaspartate (NMDA)IBA 07/2013
1	Antidepressive Agents (Antidepressants)IBA 07/2013
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 02/2013
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 02/2013
1	Indicators and Reagents (Reagents)IBA 02/2013
1	trkB ReceptorIBA 02/2013
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 08/2012
1	kynureninaseIBA 08/2012
1	3-Hydroxyanthranilic AcidIBA 08/2012
1	Transaminases (Aminotransferases)IBA 08/2012
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 08/2012
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 02/2012
1	Pharmaceutical PreparationsIBA 02/2012
1	Monoamine Oxidase (MAO)IBA 02/2012
1	NeurotoxinsIBA 11/2010
1	Kainic Acid (Kainate)IBA 11/2010
1	Sulpiride (neogama)IBA 07/2010
1	SCH 23390IBA 07/2010
1	ChemokinesIBA 03/2010
1	Cell Adhesion MoleculesIBA 03/2010

Therapy/Procedure

2	Therapeutics 01/2021 - 07/2013
2	Induced Hypothermia 08/2015 - 07/2010
1	Drug Therapy (Chemotherapy) 11/2013